Population Genetics of Polymorphism and Divergence for Diploid Selection Models With Arbitrary Dominance
نویسندگان
چکیده
منابع مشابه
Population genetics of polymorphism and divergence for diploid selection models with arbitrary dominance.
We develop a Poisson random-field model of polymorphism and divergence that allows arbitrary dominance relations in a diploid context. This model provides a maximum-likelihood framework for estimating both selection and dominance parameters of new mutations using information on the frequency spectrum of sequence polymorphisms. This is the first DNA sequence-based estimator of the dominance para...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.103.024745